Gum infection could be linked to Alzheimer’s, study says

by Noah Mcgee January 28, 2019, 0:29
Gum infection could be linked to Alzheimer’s, study says

An worldwide group of scientists from the Washington University School of Medicine and the German Center for Neurodegenerative Diseases, Germany, have developed a new simple blood test that can predict the risk of having Alzheimer's 16 years before the emergence of symptoms.

A team of scientists from the University of Louisville found P. gingivalis in the brains of deceased people who suffered from Alzheimer's. In these lab experiments, scientists were able to reduce the number of Porphyromonas gingivalis bacteria in the infected brains, block the production of toxic proteins, and halt degeneration in the brain.

Other research has looked at whether various bacterial, viral, or fungal infections may play a role in Alzheimer's, but there is now not enough evidence to say.

Researchers have linked a gum disease to Alzheimer's in a study.

It's possible that news of the possible link will lead to people spending more time on their dental health than they now do, though: One study found less than one third of Americans floss daily.

In addition, the researchers found that Hispanics with AD showed greater small blood vessel disease in the brain than non-Hispanics with AD, as well as increased amyloid angiopathy, the accumulation of protein fragments in blood vessels associated with AD. Higher levels gingipain were associated with tau and ubiquitin, two other proteins involved in the development of Alzheimer's. The study also finds that in mice, the bacteria trigger brain changes typical of the disease.

An incredible discovery by medical researchers could change the treatment of Alzheimer's disease as we know it, now that a simple blood test could identify the condition over a decade before it sets in. Results showed mouse ISF tau was increased by up to 90% during wakefulness vs sleep and up to 100% during SD; human CSF tau increased over 50% during SD; in tau seeding and spreading model chronic SD increased tau pathology spreading; chemogenetically driven wakefulness in mice significantly increased ISF Aβ and tau.

Netflix Goes Against The Stream With Its First Best Picture Oscar Nomination
In the realm of snubs, none stung quite so loudly as Bradley Cooper failing to show up on the Best Director list. After directing for decades, Spike Lee received his first best director nomination.

The families form the study population of the Dominantly Inherited Alzheimer's Network (DIAN), an worldwide consortium that is investigating the roots of Alzheimer's disease.

"Infectious agents have been implicated in the development and progression of Alzheimer's disease before, but the evidence of causation hasn't been convincing", said Stephen Dominy, M.D., Cortexyme co-founder and lead author on the paper.

The provocative findings are the latest in a wave of research suggesting microbial infections may play a role in Alzheimer's disease.

Researchers looked at brain tissue from autopsies of individuals with and without Alzheimer's disease and found a majority of those with the disease had higher levels of an enzyme called gingipains, which is produced by P. gingivalis. Chief executive Casey Lynch said: 'This study is an important breakthrough in understanding how Alzheimer's disease can be triggered and a new path to treatment'.

"The interesting thing about this study is that it suggests that real-life factors such as sleep might affect how fast the disease spreads through the brain", said David Holtz, senior author and head of the Department of Neurology. Madison Hospital is already testing new solutions for patients, like using special pillows as a visual cue to let hospital staff know a patient has Alzheimer's. Bacteria that cause a common yet largely preventable gum infection may also play a role in Alzheimer's disease.

They found P. gingivalis DNA in 7 out of 10 cerebrospinal fluid samples of people with Alzheimer's disease and all 10 matched saliva samples. Later this year the firm will launch a larger trial of the drug, looking for P. gingivalis in spinal fluid, and cognitive improvements, before and after.

Recommended News


TOP News

Family Kicked Off Airplane, Forced To Miss Flight Over Bad ‘Odor’
An American Airlines jet taxis on the runway at Washington National Airport in Washington, U.S., August 9, 2017. A Detroit couple and their infant daughter were kicked off an American Airlines flight from Miami this week.

Nadal, Sharapova, Wozniacki, Federer advance; Murray out at Australian Open
Kerber said her form improved during the match and her ball-striking was not side-tracked by the at-times inconsistent opponent. Fifth-seeded Kevin Anderson won his first match at Melbourne Park since 2015 when he beat Adrian Mannarino 6-3, 5-7, 6-2, 6-1.

Death toll from Kenya hotel attack rises to 21
His mother Sarah told NBC News that her son "was trying to make positive change in the third world in emerging markets". He was having lunch at the targeted complex of the firm when the attack occurred, according to Spindler's colleagues.

Denver Broncos hire 49ers QB coach Rich Scangarello as offensive coordinator
Broncos Blitz podcast host Ronnie Kohrt breaks down the strengths and weaknesses of the new coaching staff. In 2005, Pariani entered the collegiate world as Syracuse's offensive coordinator for one season.

Andy Reid has the most to gain, lose in conference championship games
The Chiefs allowed 5.0 yards per carry against opposing offenses this year, second-worst in the league. Just like in that matchup, I believe the total has been set too high in tonight's AFC title game.

Israel launches airstrikes on Iranian forces in Syria
Syria's air defense systems repelled an Israeli air attack in the country's south, the SANA news agency reported on Sunday. Syria's Pantsir and Buk air defense missile systems were used to shoot down Israeli rockets and knocked out seven of them.

Chinese Super League Giants Set Sights On Mesut Ozil
I want every player to give the same work every day to be OK for every match. What is most important is how he can help us".

Petra Kvitova: 'Just a few people believed I could do it again'
After Kvitova double-faulted to offer up a break point at 1-all, Osaka converted it with a cross-court backhand victor . Behind a tennis player is always a team and I am really grateful, so thank you guys.

Kremlin Had No Contacts Regarding Construction of Trump Tower in Moscow - Peskov
The president's former fixer Michael Cohen has already pleaded guilty to lying to Congress about the timeline, having falsely claimed the negotiations ended almost a year before.

South Korea stops calling North 'main enemy'
Asked about the prospect of Kim Yong Chol visiting Washington for the second time in less than a year, the U.S. State Department demurred, telling The Japan Times that it did not have any meetings to announce.